THE ALPHAFOLD NETWORK
By comparing and analysing protein structures, it is possible to get ideas about biological evolution, diseases, defence mechanisms, etc. This explains the human quest for finding the structures of proteins. In 1972, Christian B. Anfinsen won the Nobel Prize in Chemistry for his experiments that showed that a protein could fold into its structure based on the information contained in the sequence of amino acids. Max Perutz and others experimentally determined the first protein structures of myoglobin and haemoglobin. They did this through a method called X-ray crystallography that uses protein crystals and X-rays. India has had a legacy of being a top player in the field of protein structural work, both experimental and computational. The Ramachandran Plot devised nearly 60 years ago by G.N. Ramachandran and others from the University of Madras is used even today the world over to validate protein structures. In 1994, John Moult and his colleagues started an ex...