THE CLICK CHEMISTRY
Synthesis is the oldest & main theme in chemistry. Twenty years ago,M. G. Finn, Hartmuth C. Kolb & K. Barry Sharpless tried to define one style of synthesis by focusing on its reasons of existence : achieved a new molecular behaviour (function) rather than appearance (structure). They named it “click chemistry”,meant to easily connect two objects. After long term experiments in two sectors, polymer chemistry and biochemistry , concluded that, that reliable connectivity enables molecules of complex function to be easily assembled. Click chemistry links proteins, lipids, nucleic acids, and carbohydrates to partner molecules with high efficiency, under physiological conditions, and without toxic catalysts or byproducts. These partner molecules include reporters & imaging agents, allowing the in vivo visualization and tracking of biomolecules and cells. Polymers, providing scaffolds for tissue engineering;...